Scientists say the opening of bad breath gene

Bad breath is not always associated with poor hygiene of the oral cavity. Scientists say that in about 0, 5 to 3 percent of the people cause bad odors are other sources. For example, a bad smell occurs when inflammation of sinus cavities, esophagus, lung diseases, and even because of the peculiarities of blood. Nevertheless, the causes of the stench, scientists do not fully established. But it seems that the answer has found an international group of researchers, who discovered another potential "external" source of bad breath - genes.

Scientists say the opening of bad breath gene

The researchers conducted the study SELENBP1 protein and discovered that mutations in the gene, it may cause the body to produce malodorous molecules. At the same time, it is no less interesting, this gene may play a role in suppressing the development of tumors.

"It is important to establish the true cause persistent bad breath and be able to understand, there is the relatively harmless situation - diseases of the gums, for example, or a dangerous condition - the same cirrhosis" - Professor Kent says Lloyd of the University of California Davis.

According to published in the scientific journal Nature Genetics article, the researchers studied five volunteers whose breath was like the smell of boiled cabbage. First, they exclude other potential sources of bad breath - diet, for example, and then analyzed using breathing equipment for gas chromatography. We are talking about high-tech artificial "nose". As a result, it turned out that the scent created by a number of sulfur-containing molecules (e.g., methanethiol and dimethylsulfide). The researchers note that the same methanethiol is usually formed in the digestion process, but cleaved in the body. In all patients, as it turns out, there is one common item. The researchers noted that each of them there was a mutation in the gene SELENBP1. In addition, all also experienced a high level of methanethiol and dimethyl sulfide in the blood. When the blood reaches the lungs, these smelly sulfur compounds and leaving it with the exhaled air.

The researchers decided to find out whether this gene is indeed the cause of odor. To do this, they conducted an experiment in which in laboratory mice, this gene has been "turned off". Scientists have discovered that there are much higher levels of these odorous sulfur compounds (as well as in people with a mutation in the gene being studied) in the blood plasma of all mutant rodents. Thus, researchers have shown that the mutation in SELENBP1 gene leads to the production of unpleasant odors (due to the production of certain proteins).

The experimental results showed that, perhaps it SELENBP1 responsible for producing the enzyme that destroys odorous molecules. The study authors write that one of SELENBP1 probability function can be to maintain a low concentration of exhaled methanethiol, but the available mutation disrupts this process.

Scientists say the opening of bad breath gene

Unfortunately, the card in this case not only supplied fresh breath. As part of an earlier study, researchers carried assumption that SELENBP1 may play a role in suppressing the development of cancer. Then it was noted that dogs are able to feel the "smell" of some tumors (eg breast cancer). Perhaps this is due to the fact that such diseases smell compounds, which have not been destroyed by proteins, which are responsible SELENBP1. And this "smell" the animals feel. However, at the moment this is just an assumption. Currently there is no method for treating bad breath (oral hygiene it merely masks). However, genetic studies and a more complete understanding of this problem can help in the future to develop a specific treatment.