Scientists have created a molecule that can neutralize influenza virus
According to the World Health Organization every year in the world is celebrated from 3 to 5 million cases different types of influenza virus, with up to 650 000 cases are fatal. Unfortunately, even in the modern world, science has not come up with a universal cure for the most common "seasonal disease." This is explained by the fact that the virus mutates easily, which makes professionals to create more and more new types of vaccines. At the same time, the principle of vaccination is based mainly on preventing disease. But it does not guarantee that you will end up not pick up any new form of the virus.
The international team of scientists from the US, the Netherlands and Belgium, recently published an article in which the principle of the experimental drug JNJ4796 described in detail, created on the basis of special selected molecules that mimic the behavior of neutralizing antibodies. These molecules bind to the virus hemagglutinin (protein on the surface of viral particles) and neutralized serotypes of influenza A virus by blocking its spread throughout the body.
Laboratory tests of the drug on mice infected with lethal doses of influenza virus. First rodents administered a drug at a dose of 50 and 10 mg / kg per day prior to challenge and then at the same dosage for seven consecutive days. The drug contributed to the normalization of the status of rodents, but they continued to lose weight. Then the scientists have made about changing the dose solution by reducing them to the 5 and 15 mg / kg, but increased the number of them receiving up to two times a day. It is these proportions guarantee the survival of the mice. As they note, the molecule prevented the development of the influenza virus in the body, triggering recovery mechanism before the infection spreads. As a result, the rodents that received molecule recovered.
Additional studies were conducted on vaccines grown in vitro human lung tissue cells. The results also proved to be positive - the drug will completely get rid of the virus particles. All this opens up the potential for drug testing involving humans.
"If you told me 10 years ago said that we will have such a molecule would be that I really did not believe it. Nevertheless, we have created a molecule prove that they are able to behave as a very powerful antibodies ", - said Ian Wilson, co-author of the study.
The next stage of the study a potential new method for dealing with the flu should become an experiment involving human subjects.
Discuss the news may be in our Telegram-chat.