Editor CRISPR genome was first used for the treatment of HIV

CRISPR genome editor is increasingly used in medicine for the treatment of patients. This is what we regularly soobschapem on our portal. So if you do not want to miss the news, be sure to subscribe to our channel Telegram. Whereas previously all been limited to a series of experiments in the laboratory or in the best case, experiments on animals, now scientists are using advances in CRISPR to help people. For example, recently Chinese medical CRISPR used to edit the immune cells from a patient suffering from HIV. And this therapy has been to some extent very successful.

Editor CRISPR genome was first used for the treatment of HIV

genome Editor - a powerful tool that can help us to overcome incurable diseases

As editor of the genome will help cure HIV

In order to help a person, doctors decided to use a mutation CCR532. It is open for a long time. And this rare mutation makes human T-cells (responsible for immunity) resistant to HIV infection. The patient 33 years, participating in the experiment, in addition to diagnosed HIV also was discovered and T-cell leukemia. This complicated process. So people should be treated by radiotherapy, which kills most of the T cells. And since they are responsible for immunity, after receipt of such a treatment, the patient could die very quickly due to the rapid spread of the organism immunodeficiency virus. As a result, scientists have decided to combine the treatment with the experimental procedure: after irradiation they entered the patient has been edited using a CRISPR its own cells, which had been "introduced" the aforementioned mutation CCR532. CRISPR-modified cells have taken root in the body. Most interesting is that 19 months after the experiment, the cells with the mutation is still detected in the patient's body. Moreover, the mutation passed on to other cells in the blood, rather than just a new T-lymphocytes.

See also: finally began large-scale testing of a vaccine against HIV.

However, the number of these cells was still not sufficient to completely cure the patient from the dangerous virus. The percentage of "mutated" cells was 17 8% at the start of the experiment, and about 8% after 19 months after the first administration of CRISPR-modified cells.

Editor CRISPR genome was first used for the treatment of HIV

The process of editing the genome looks like. Part of the gene is cut out and replaced with new

Nevertheless, the authors of the work are confident that their study successfully. On the one hand - this is the longest to date monitoring of the CRISPR-edited cells in the human body. On the other hand, scientists have shown that even a long stay in the body of the edited cell does not bear the additional harm to the body. And, importantly, against the background of a patient's cancer, new cells are not transformed into tumor cells, which scientists fear most. Moreover, in theory, if we increase the number of CRISPR oxide modified cells in the human body, it will be possible to achieve regression of the virus and possibly even a complete cure. Now the Chinese doctors are looking for ways to create populations of cells that could "survive" in the body much longer to "replace" all the blood cells with new ones, and thus try to cure the patient from the dangerous disease.